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FYI

NNY Autism Center

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  • CBC with a differential
  • CMV IgG / IgM (if the IgG is positive)
  • ANA titer
  • EBV IgG / IgM (if the IgG is positive)
  • Sedimentation rate
  • Hypothyroid panel
  • Ferritin level

An Immune Panel

  • CD 4   (total and %)
  • CD 8   (total and %)
  • CD 16 / CD 56 (total and %)
  • CD 19 (total and %)
  • Lead level
  • Vitamin B-12 level
  • Folic Acid
  • SGOT / SGPT
  • Comprehensive metabolic panel
  • Lipid panel
  • Candida Titer (IgG, IgA, IgM)
  • HHV6 Titer
  • Quantatative Immunoglobulins (IgG, IgA, IgM, IgE)
  • Gliadin Antibodies

Other Tests That May Be Helpful

  • Coxsakie Virus A & B
  • Rubella IgG Titer
  • Thyroid Antibodies
  • Herpes I & II (IgG / IgM)
  • Allergy Food Screen
  • Alpha Interferon
 
Understanding Lab Terminology
 
Eos - part of the CBC (complete blood count) that indicated whether your child has problems with allergies and a good indicator for determining if the diet is being followed.  The ideal result would be between 1-2%.
 
NK - Natural Killer cells are are the soldiers of the immune system, the first line of defense against mutant and virus infected cells.  They bind to their target and then deliver a lethal burst of chemicals that produce holes in the target membrane and the cells eventually bursts.  A value below 4-5% is of concern.
 
Ferritin - indicates the amount of iron stored.  If the level becomes too low it will interfere with your child's growth and development and a supplement may be ordered.  
 
Gliadin - IgG, IgA positive results indicate that your child is not tolerating wheat protein.  Keep in mind a negative test result does not indicate that he can now eat wheat;  it may suggest that the immune system is so compromised that it can't make that particular antibody at this time.
 
ANA -  A positive Antinuclear Antibody means that tne body is making anitbodies against its own cells; the immune system is not functioning correctly.
 
Immunoglobulins
Immunoglobulins (antibody) test is done to measure the level of antibodies in the blood.
 
Antibodies are usually specific to each type of foreign substance and sometimes they are produced against a person's own tissues, which is called an autoimmune disease.
 
Low levels of antibodies increase the risk of developing repeated infections.  A person can be born this way or the production of low antibody levels may be in response to a disease.
 
Types of antibodies:
  • IgA - found mainly in the nose, digestive tract, ears, breathing passages, eyes, and vagina and also in tears and saliva.  Levels increase in autoimmune diseases.  Low levels can indicate a problem with the intestines.
  • IgG - High levels indicate chronic infection.
  • IgM - High levels can indicate a new infection.
  • IgE - A parasite infection can be indicated in high levels and is a common finding in those with allergic reactions.
 
 
How To Administer Ear Drops To Your Child
  1. Read the instructions carefully, always wash your hands and shake the bottle.
  2. Warm the medicine to body temperature by holding the bottle between your hands for several minutes; cold medicine placed in the ear can cause dizziness or nausea.
  3. Place the child on his side so that the affected ear is on top.
  4. For a child less than 3 years old straighten the ear canal by holding the ear lobe and pulling down and back.
  5. For a child over 3 years old hold the upper part of the ear and pull up and back.
  6. Drop the correct number of drops into the ear but do not touch the dropper to the ear. Try to place the drops onto the side of the ear canal and not directly down the ear canal. 
  7. Keep child on his side for 5 minutes.

Mold:  Things You Should Know

  1. Allergic reactions, asthma, and other respiratory complaints are potential health effects and symptoms associated with mold exposure.
  2. You have to control indoor moisture to eliminate mold and mold spores.
  3. Molds can be found anywhere; they grow on virtually any substance where moisture is present. Dry water damaged areas within 24-48 hours to prevent mold growth.
  4. Never install carpeting where there is a moisture problem.
  5. Add insulation to prevent possible condensation on cold surfaces.
  6. Clean mold off hard surfaces with water and detergent or bleach and dry completely. Absorbant materials like ceiling tiles or carpet that are moldy have to be replaced.
  7. Vent bathrooms, dryers and other moisture generating sources to the outside. Use de-humidifiers and exhaust fans when cooking or using a dishwasher.
  8. Fix all water leaks to prevent mold growth.

To check pollen and mold levels in your area visit www.weather.com .  It's always a good idea to keep a journal so that you can correlate health issues with what is going on in the immediate environment.

Resources for asthma information and control are:

Human Herpesvirus 6 (HHV-6)

The HHV-6 virus is NOT the virus that causes cold sores, genital herpes, chicken pox, shingles, or infectious mononucleosis.  It is the cause of roseola (exanthem subitum). The virus was discovered in 1986 in the USA at the National Cancer Institute.  It infects human white blood cells, specifically T lymphocytes.

Symptoms of this illness include fever and a distinct rash. Usually children are infected with HHV-6 before age two and many display mild or no symptoms.  Some infected infants may develop serious disease including brain infection (seizures), bone marrow infection (decreased production of white blood cells and platelets).

Transmission of this virus is thought to occur as a result of exposure to saliva. Once the initial infection has been made the HHV-6 viral DNA remains latent or dormant within the nuclei of the cells.  HHV-6 is one of the eight known members of the human herpesvirus family.  Approximately 95% of the world's population is positive for antibodies to HHV-6 which indicates an immune response to an infection by the virus.

Immunizations

To date there is no documented proof that immunizations cause autism, however that being said, it is questionable if in fact these injections don't serve as a trigger for some kids causing them to demonstrate autistic symptoms.  Research continues with a focus on this subject.  Studies have been done in England, Sweden, Denmark and the US.

The MMR vaccine (measles, mumps, rubella german measles) is given to children between the ages of 15 months and the second injection is given between 2-6 years of age.  It appears that there is a greater risk if the MMR is given before the age of 3 years old, according to the studies.

It was also reported that the causes of autism appear to be both genetic and environmental.  Other conculsions of those at higher risk for autism spectrum disorders (ASD):

  • autism is 75% higher in both twins if they are identical
  • the incidence of autism in non-identical twins is 3% for both
  • siblings have 2-6% risk of developing autism
  • risk is higher with certain medical conditions

Examples:  Fragile X Syndrome, Tuberous Sclerosis, Congenital  Rubella Syndrome

  • there is a high risk of autism if harmful substances were ingested during the pregnancy

The other concerns were the neurodevelopmental effects from the mercury found in Thimerosal used in some vaccines before 1999.  Thimerosal is no longer used in immunization vaccines, however, it is used in the flu vaccine.

A study conducted in Sweden by Gillberg and Heijbel, involved 55 known cases of autism, and evidence of association between the MMR vaccine and autism.  The sudy compared autism from two communities in Sweden.  The results indicated no difference in the prevalence rates between children born after the introduction of the MMR vaccine in Sweden and those born before the vaccine was used.

The National Immunization Program (NIP) and the Developmental Disabilities Branch of the CDC are conducting a study to examine whether the timing of vaccines administered before the age of 2 years differs with children with autism as compared with the control children.

More Autism Facts 

  • 1 in 150 births
  • 1 to 1.5 million Americans are affected
  • fastest growing developmental disability
  • 10 - 17 % annual growth
  • growth comparison during the 1990's:

       U.S. population

       increase:

       13%

      Disabilities increase:

      16%

      Autism increase:

      172%

  • $90 billion annual cost
  • 90% of costs are in adult services
  • Cost of lifelong care can be reduced by 2/3 with early diagnosis and intervention
  • In 10 years, the annual cost will be $200 - $400 billion

Autism News August 2006
 

DIFFERENT GENES MAY CAUSE AUTISM IN BOYS AND GIRLS
 
Gerard Schellenberg, a researcher at the Puget Sound Veterans Affairs Medical Center and a research professor of medicine at the Universoty of Washington, headed a research project that strongly suggests that there may be 4 to 6 major genes and 20 to 30 others that might contribute to autism.  Critical evidence was discovered after 10 years of research for two genetic subtypes of autism, male versus female and early versus late onset.  This study was published this month in the online journal Molecular Genetics.
 
The research produced strong support for an autism gene on chromosome 7 and some evidence for genes on chromosomes 3,4, and 11.  Once these susceptibility genes are discovered the underlying cause of autism at the molecular level will be known.
 
The research is part of the National Institute of Child Health and Human Development Collabrative Program of Excellance in Autism and is ongoing.  Families with more than one child of any age with an autism spectrum disorder who are interested in participating in the UW genetics study can call toll free 1-800-994-9701.
 
Co-authors of the paper are Yun Ju Sung, Annette Estes, Jeff Munson, Elisabeth Rosenthal and Joseph Rothstein of the Univ. of Washington; Leslie Leong and Chang-En Yu of the Puget Sound Veterans Affairs Medical Center; Patricia Rodier of the Univ. of Rochester Medical Center; M. Ann Spencer of the Univ of California, Irvine; Nancy Minshaw of the Univ of Pittsburg; and William McMahon of the Univ. of Utah.
 
 
CURE AUTISM NOW CELEBRATES SENATE APPROVAL OF COMBATING AUTISM ACT OF 2006
 
The Combating Autism Act authorizes $900 million for autism-specific funding.  The landmark act now moves to the House of Representatives for approval before it can be signed into law.  Once it is signed it will be one of a very few "single-disease" legislation.
 
Act Highlights:
  • Allocates approximately $900 million in spending on autism over the next 5 years.
  • Authorizes a 50% increase in spending for biomedial research in autism from the $100 million which the NIH currently claims to be spending.
  • Creates a legal requirement for Centers of Excellence in Environmental Health and autism, to research "a broad array of environmental factors that may have a possible role in autism spectrum disorders."   These Centers are authorized with funding of $45 million over the next 5 years.
  • Requires the director of NIH to develop and implement a strategic plan for autism research and a budget to fund this plan, accounting for public/private committee recommendations (the Interagency Autism Coordinating Committee) which it requires to include at least one-third public members, including a person with autism and a person who is the parent of a child with autism.  This new authority and accountability makes the director, in effect, the "autism czar."
  • Most importantly, provides grant programs for states to develop autism screening, early diagnosis, and intervention programs for children.

 

 
More Evidence of The Immune System Link
 
UC Davis researchers reported that autistic children have abnormalties in their immune systems and unusal constellations of proteins in their blood that may be an indicator of the disorder.  These findings suggest the possibility for diagnostic tests for autism at birth.
 
Two goups of researchers from the MIND Institute at UC Davis have reported that autistic children have a dysfunctional immune system which gives them an abnormal response to pathogens and other agents.  Immune abnormalities might be a marker of autism susceptibility that was present at birth, and development of the disorder could require exposure to an environmental trigger.
 
LA Times May 2005
 
Finding the Cause of Autism
 
Vijendra K. Singh, Ph.D. was one of the first to conduct research based on the hypothesis that one of the primary triggers of autism pathology may involve faulty immune regulation, in particular, autoimmunity.  In 1992 Singh conducted a study which linked autism to heightened autoimmunity, finding autistic children have about eight times greater incidence of antibodies to myelin basic protein (MBP) than control children.
 
In 2001 Singh published a study in which he suggested that the MMR vaccinated children have abnormally high levels of measles virus antibodies, indicating autism may be a neuro-immune response to the vaccine.  He found that 55% of autistic children developed their condition after receiving the MMR vaccine and 33% after receving the diptheria, tetanus and pertussis (DTP) vaccine.  80% of the autistic children had auto-antibodies while normal children had none.  These auto-antibodies appear to attack the protective myelin sheathing of nerve fibers, resulting in brain dysfunction.
 
 
Siblings of Autistic Children
 
Dr. Wendy Roberts at the Hospital for Sick Children in Toronto studied 150 siblings of autistic siblings.  19 had distinctive patterns of conduct as early as 1 year old.  Among other symptoms, the children made little eye contact, even with parents, had trouble displaying emotions with their faces, such as smiling.  Siblings have a substantial risk of developing the disorder as much as 50 times the risk of the general population.  All 19 did develop autism.
 
LA Times May 2005
 
How To Administer Eye Drops To Your Child
  1. Always wash your hands before giving medication.
  2. Be sure the eye drops are at room temperature before using.
  3. Clean the child's eye of all secretions and / or old medication.  This can be done by gently wiping the eye with a damp gauze or a cotton pad.
  4. Have your child stand or sit with his head tilted back.
  5. Do not touch the dropper bottle to the eye.
  6. Have the child look upward toward the ceiling.  Use your index finger and thumb to gently pinch and pull down the lower lid to create a pouch.  Drop the prescribed number of drops into the pouch and not directly into the eye.
  7. Have the child close his eyes for 1-2 minutes.
  8. If a 2nd eye drop is prescribed, wait at least 5 minutes before giving it.

(Opthalmic refers to eye)

Neurontin

Neurontin is not metabolized by the liver it is excreted through the kidneys.  It is important to increase water intake while on this medication.  A small amount of water retention is normal especially with increasing doses. Drinking extra water will help in eliminating  excess fluid accumulation. 

Problems of Autism Explained In New Research

Using magnetic resonance imaging (MRI) technology researchers from Melbourne's Howard Florey Institute have shown that children with autism have less activation in the deep parts of their brain.  This is the area that is responsible for executive function such as: attention, reasoning and problem solving.  Boys with autism had reduced activity in the caudate nucleus, a critical part of circuits that link the prefrontal cortex of the brain.

This information has an important implication since prefrontal brain circuits play a critical role in focusing attention, planning and setting goals, and keeping goals in memory during problem-solving and decision making.  This discovery may help develop better therapies to improve their ability to pay attention and solve problems. 

Primary Differences In Herpes Simplex Virus (HSV I & II)

HSV I: Causes cold sores, usually under the lip.  It establishes latency in trigeminal ganglion (nerves near the ear).

  • Myth:  It is never dangerous.
  • Fact:  It can recur spontaneously in the eye, which can cause blindness.  In rare cases it can spread to the brain (herpes encephalitis) and can cause death.  It is also the usual cause of Herpes Whitlow (infection in the finger) and "Wrestler's Herpes."

HSV II: Establish in sacral ganglion at base of spine

  • Recurs in the gential area.
  • Causes genital herpes.

 Note:  Either HSV I or HSV II can reside in either or both parts of the body.  The misconception of this and the lack of symptoms can and does contribute to the spread of Type I.  One is associated with sigma and the other is "just a cold sore."

  • Both look the same under a microscope;
  • Both infect the body's mucosal surfaces (mouth and genitals) and then establish latency in the central nervous system;
  • Both result with 2/3 being asymptomatic or have mild symptoms;
  • Both can recur and spread with no symptoms present.

The Other Side of ADHD

Often a child who displays that he/she is out of control in the classroom will get misdiagnosed with ADHD when in fact the problem may be a lack of discipline while in the same classroom a classmate habitually forgets their papers or stares out the window for long periods of time or shows many other recognizable signs.  Getting the correct diagnosis is key to the treatment.

ADHD is a serious disorder, however, there are those who have a different perspective noting the positive aspects.  For example:

  • compulsivity - willing to take risks rather than waver on making a decision.
  • learning process - with the effective teaching strategies they can actually learn faster with more comprehension.
  • impulsivity - they are eager to jump into a situation while others may be uneasy

Many famous people were thought to have the diagnosis of ADHD or might have been had the current criteria been available such as:

  1. Thomas Edison
  2. Walt Disney
  3. Hans Christian Anderson
  4. Beethoven
  5. Theodore Roosevelt
  6. Winston Churchill
  7. Ben Franklin
  8. Robert Kennedy
  9. John F. Kennedy
  10. Woodrow Wilson
  11. Robin Williams
  12. Dustin Hoffman
  13. Wright brothers

Remember, hyper focus is not always a bad thing. Learning appropriate coping skills can be used to attain great accomplishments.

What Can the Thyroid  TSH Test Reveal?        

The TSH test measures the concentration of thyroid-stimulating hormone levels in the blood.  TSH is the pituitary gland's signal to your thyroid gland to make less or more thyroid hormone. The pituitary is constantly monitoring the amount of thyroid hormone that is in the blood. It is the most important single method of monitoring thyroid function for any changes that may have occurred.

A high level of TSH usually means that your pituitary senses that there is not enough thyroid hormone in your blood and it is trying to get the thyroid gland to make more.

If there is a low level of TSH, it usually means that your pituitary senses that there is too much thyroid hormone in the blood, and it has decreased its TSH signal

To Learn More About NeuroEndocrineImmune Dysfunction Join A New Online Group

 
This group offers access to many research articles and many years of experience. This is a private group which requires that you must apply to join.  Click on the link below.
 

Allergen Removal 101
 
To reduce triggers to your child's immune system it is important to remove allergens.  Dust mites are reduced when you cover your child's pillow and mattress with covers that are made to keep in allergens. 
 
In a recent report in the field of allergy it was noted that not only are pillows a safe haven for dust mites but also for mold!  Synthetic fillers are especially prone to mold spores, however, don't think that using a feather pillow averts dust mites; they love natural fibers too. Inhaled mite waste causes allergic problems.  Cover pillows and mattresses with good allergen covers and wash them regularly in hot water.
 
Why Isn't My Child Talking Yet?
 
The job of the biomedical protocol is to make your child's brain healthier.  When your child's brain starts becoming healthier he will be able to start learning.  
 
Have you ever noticed how parents of toddlers teach their children?  They talk to their babies, repeat sounds and when the babies respond they give them feedback.  Have you ever watched a mother at the supermarket interacting with her baby?  You will most likely hear a constant stream of conversation.  Do you do this?  Do you expect one hour of speech therapy three times a week to make your child talk?  Are you asking the speech therapist to send homework home?  Are you talking to your child?  Do you listen and watch?  Do you expect your child to answer or are you anticipating their needs and wants and eliminating the necessity of speech? 
       
There are many reasons that a child will not speak and each child is unique.  Some may require more encouragement than others while some just need a receptive audience that can take the time to encourage them.  Talk to your child's speech therapist and find out what you can be doing at home.  Take a good look at yourself and your family and think about what you are currently doing and what you can change.  We are all differently gifted and perhaps you are not the best person to work with your child.  If  this applies in your situation then perhaps you can think of someone else who could work with your child.
 
A few years ago we brought Dr. James MacDonald, a specialist in parent and child communication, here from Ohio.  His workshop was on communication.  We have some of his tapes and they are available from our lending library.  He has some thought provoking ideas and a very helpful website at www.jamesdmacdonald.org .  
 
He steps back and observes and listens when he is evaluating a child.  When he sits down on the floor and interacts with the child the child gives the cues and Dr. MacDonald responds and then he watches the parent interact with the child.  That is the basis for how language is learned.  Sound familiar?  The baby in the grocery cart cooes and the mother responds.  All too often the parent does all of the leading and the child follows, quietly.  Take the time to look at the dynamics in your home.  You have to get more involved at home for speech to begin so make a plan now or if your current plan is not working get together with other family members and develop a new one.

Copyright 2008, NNY Autism Foundation Inc.